Question

I am a breastfeeding mother and i want to know if it is safe to use AI3-52216? Is AI3-52216 safe for nursing mother and child? Does AI3-52216 extracts into breast milk? Does AI3-52216 has any long term or short term side effects on infants? Can AI3-52216 influence milk supply or can AI3-52216 decrease milk supply in lactating mothers?

AI3-52216 lactation summary

AI3-52216 is dangerous in breastfeeding
  • DrLact safety Score for AI3-52216 is 7 out of 8 which is considered Dangerous as per our analyses.
  • A safety Score of 7 indicates that usage of AI3-52216 may cause toxic or severe side effects in breastfed baby.
  • Our study of different scientific research indicates that AI3-52216 may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using AI3-52216 .
  • Usage of AI3-52216 is in contradiction to breastfeeding hence if it is must to use AI3-52216 and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About AI3-52216 usage in lactation

Drug is cleared from the body after 25-50 elimination half-life. Resuming breastfeeding is likely safe after 48 hours of pump-and-dump.

Answer by DrLact: About AI3-52216 usage in lactation

No information is available on the use of AI3-52216 during breastfeeding. Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, especially alkylating agents such as AI3-52216.[1] The manufacturer recommends that breastfeeding be discontinued during AI3-52216 therapy and for 1 month after the last dose.

AI3-52216 Possible Effects in Breastfeeding

Some evidence indicates that AI3-52216 can increase serum prolactin.[2]

Alternate Drugs

Bendamustine
Carmustine(Dangerous)
Temozolamide
Dacarbazine(Dangerous)
Bendamustine
Carmustine(Dangerous)

Synonyms of AI3-52216

BCNU
Bi CNU
BiCNU
Bischlorethylnitrosourea
Bischlorethylnitrosurea
Bischloroethyl nitrosourea
Bischloroethylnitrosourea
1,3-Bis(beta-chloroethyl)-1-nitrosourea
1,3-Bis(2-chloroethyl)nitrosourea
1,3-Bis(2-chloroethyl)-1-nitrosourea
Bis(2-chloroethyl)nitrosourea
Bis(2-chloroethyl)1-nitrosourea
BRN 2049744
Carmubris
Carmustin
Carmustina [INN-Spanish]
Carmustinum [INN-Latin]
CCRIS 810
EINECS 205-838-2
FDA 0345
Gliadel
NCI-C04773
Nitrumon
NSC-409962
SK 27702
SRI 1720
NSC 409962
DTI 015
Becenum
Carmustina
Carmustinum
UNII-U68WG3173Y
HSDB 7761
gliadel wafer
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.