Is 1,3-Bis(2-chloroethyl)-1-nitrosourea Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 1,3-Bis(2-chloroethyl)-1-nitrosourea? Is 1,3-Bis(2-chloroethyl)-1-nitrosourea safe for nursing mother and child? Does 1,3-Bis(2-chloroethyl)-1-nitrosourea extracts into breast milk? Does 1,3-Bis(2-chloroethyl)-1-nitrosourea has any long term or short term side effects on infants? Can 1,3-Bis(2-chloroethyl)-1-nitrosourea influence milk supply or can 1,3-Bis(2-chloroethyl)-1-nitrosourea decrease milk supply in lactating mothers?
1,3-Bis(2-chloroethyl)-1-nitrosourea lactation summary
- DrLact safety Score for 1,3-Bis(2-chloroethyl)-1-nitrosourea is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of 1,3-Bis(2-chloroethyl)-1-nitrosourea may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that 1,3-Bis(2-chloroethyl)-1-nitrosourea may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using 1,3-Bis(2-chloroethyl)-1-nitrosourea .
- Usage of 1,3-Bis(2-chloroethyl)-1-nitrosourea is in contradiction to breastfeeding hence if it is must to use 1,3-Bis(2-chloroethyl)-1-nitrosourea and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 1,3-Bis(2-chloroethyl)-1-nitrosourea usage in lactation
Drug is cleared from the body after 25-50 elimination half-life. Resuming breastfeeding is likely safe after 48 hours of pump-and-dump.
Answer by DrLact: About 1,3-Bis(2-chloroethyl)-1-nitrosourea usage in lactation
No information is available on the use of 1,3-Bis(2-chloroethyl)-1-nitrosourea during breastfeeding. Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, especially alkylating agents such as 1,3-Bis(2-chloroethyl)-1-nitrosourea.[1] The manufacturer recommends that breastfeeding be discontinued during 1,3-Bis(2-chloroethyl)-1-nitrosourea therapy and for 1 month after the last dose.
1,3-Bis(2-chloroethyl)-1-nitrosourea Possible Effects in Breastfeeding
Some evidence indicates that 1,3-Bis(2-chloroethyl)-1-nitrosourea can increase serum prolactin.[2]