Is Bis(2-chloroethyl)nitrosourea Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Bis(2-chloroethyl)nitrosourea? Is Bis(2-chloroethyl)nitrosourea safe for nursing mother and child? Does Bis(2-chloroethyl)nitrosourea extracts into breast milk? Does Bis(2-chloroethyl)nitrosourea has any long term or short term side effects on infants? Can Bis(2-chloroethyl)nitrosourea influence milk supply or can Bis(2-chloroethyl)nitrosourea decrease milk supply in lactating mothers?
Bis(2-chloroethyl)nitrosourea lactation summary
- DrLact safety Score for Bis(2-chloroethyl)nitrosourea is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of Bis(2-chloroethyl)nitrosourea may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that Bis(2-chloroethyl)nitrosourea may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using Bis(2-chloroethyl)nitrosourea .
- Usage of Bis(2-chloroethyl)nitrosourea is in contradiction to breastfeeding hence if it is must to use Bis(2-chloroethyl)nitrosourea and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Bis(2-chloroethyl)nitrosourea usage in lactation
Drug is cleared from the body after 25-50 elimination half-life. Resuming breastfeeding is likely safe after 48 hours of pump-and-dump.
Answer by DrLact: About Bis(2-chloroethyl)nitrosourea usage in lactation
No information is available on the use of Bis(2-chloroethyl)nitrosourea during breastfeeding. Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, especially alkylating agents such as Bis(2-chloroethyl)nitrosourea.[1] The manufacturer recommends that breastfeeding be discontinued during Bis(2-chloroethyl)nitrosourea therapy and for 1 month after the last dose.
Bis(2-chloroethyl)nitrosourea Possible Effects in Breastfeeding
Some evidence indicates that Bis(2-chloroethyl)nitrosourea can increase serum prolactin.[2]