Is Tranylcypromine Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Tranylcypromine? Is Tranylcypromine safe for nursing mother and child? Does Tranylcypromine extracts into breast milk? Does Tranylcypromine has any long term or short term side effects on infants? Can Tranylcypromine influence milk supply or can Tranylcypromine decrease milk supply in lactating mothers?

• DrLact safety Score for Tranylcypromine is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of Tranylcypromine may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that Tranylcypromine may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using Tranylcypromine .
• It is recommended to evaluate the advantage of not breastfeeding while using Tranylcypromine Vs not using Tranylcypromine And continue breastfeeding.
• While using Tranylcypromine Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

No data are available

Because little information is available on the use of tranylcypromine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

A woman with severe depression took tranylcypromine 100 to 120 mg daily, as well as pimozide, diazepam and alprazolam during pregnancy and postpartum. She breastfed her infant until about 2 weeks postpartum when the infant developed abdominal distension and feeding intolerance. The symptoms resolved on discontinuation of breastfeeding.[1]

Nine subjects were treated with an average dose of 29 mg daily (range10 to 40 mg) of oral tranylcypromine day for an average of 16 days. Serum prolactin levels increased by 3 mcg/L.[2]The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.