Question

I am a breastfeeding mother and i want to know if it is safe to use Trimipramine? Is Trimipramine safe for nursing mother and child? Does Trimipramine extracts into breast milk? Does Trimipramine has any long term or short term side effects on infants? Can Trimipramine influence milk supply or can Trimipramine decrease milk supply in lactating mothers?

Trimipramine lactation summary

Trimipramine usage has low risk in breastfeeding
  • DrLact safety Score for Trimipramine is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Trimipramine may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Trimipramine may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Trimipramine low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Trimipramine We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Trimipramine usage in lactation

We are working on a comment for this product.

Answer by DrLact: About Trimipramine usage in lactation

If trimipramine is required by the mother, it is not a reason to discontinue breastfeeding. Because of the lack of data on use during breastfeeding, other antidepressants are preferred during breastfeeding, especially while nursing a newborn or preterm infant.

Trimipramine Side Effects in Breastfeeding

Published information on trimipramine was not found as of the revision date. Follow-up for 1 to 3 years in a group of 20 breastfed infants whose mothers were taking a tricyclic antidepressant found no adverse effects on growth and development.[1] Two small controlled studies indicate that other tricyclic antidepressants have no adverse effect on infant development.[2][3] In another study, 25 infants whose mothers took a tricyclic antidepressant during pregnancy and lactation were tested formally between 15 to 71 months and found to have normal growth and development.[4] However, none of the mothers in any of these studies took trimipramine.

Trimipramine Possible Effects in Breastfeeding

Trimipramine increases serum prolactin levels[5] and has caused at least one case of galactorrhea.[6] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed. An observational study looked at outcomes of 2859 women who took an antidepressant during the 2 years prior to pregnancy. Compared to women who did not take an antidepressant during pregnancy, mothers who took an antidepressant during all 3 trimesters of pregnancy were 37% less likely to be breastfeeding upon hospital discharge. Mothers who took an antidepressant only during the third trimester were 75% less likely to be breastfeeding at discharge. Those who took an antidepressant only during the first and second trimesters did not have a reduced likelihood of breastfeeding at discharge.[7] The antidepressants used by the mothers were not specified. A retrospective cohort study of hospital electronic medical records from 2001 to 2008 compared women who had been dispensed an antidepressant during late gestation (n = 575) to those who had a psychiatric illness but did not receive an antidepressant (n = 1552) and mothers who did not have a psychiatric diagnosis (n = 30,535). Women who received an antidepressant were 37% less likely to be breastfeeding at discharge than women without a psychiatric diagnosis, but no less likely to be breastfeeding than untreated mothers with a psychiatric diagnosis.[8] None of the mothers were taking trimipramine.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.