Is UNII-I42748ELQW Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-I42748ELQW? Is UNII-I42748ELQW safe for nursing mother and child? Does UNII-I42748ELQW extracts into breast milk? Does UNII-I42748ELQW has any long term or short term side effects on infants? Can UNII-I42748ELQW influence milk supply or can UNII-I42748ELQW decrease milk supply in lactating mothers?

Answer by DrLact: About UNII-I42748ELQW usage in lactation

No information is available on the clinical use of UNII-I42748ELQW during breastfeeding. Because UNII-I42748ELQW is over 97% bound to plasma proteins, and the half-life of the drug and metabolite are less than 7 hours, the amount in milk is likely to be low. However, the protein binding of the active metabolite is not known and the manufacturer recommends that breastfeeding be discontinued during UNII-I42748ELQW therapy and for at least 2 weeks after the final dose.

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Synonyms of UNII-I42748ELQW

Acalabrutinib [INN]

Benzamide, 4-(8-amino-3-((2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl)imidazo(1,5-a)pyrazin-1-yl)-N-2-pyridinyl-

ACP-196

Calquence

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