Is DHPG Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use DHPG? Is DHPG safe for nursing mother and child? Does DHPG extracts into breast milk? Does DHPG has any long term or short term side effects on infants? Can DHPG influence milk supply or can DHPG decrease milk supply in lactating mothers?

Synthetic nucleoside which is analogue of guanine, structurally very closed related to acyclovir.Indicated for the treatment and prevention of Cytomegalovirus (CMV) in immunocompromised patients. At latest update no published data on excretion into breast milk were found. It is used in newborns and premature who are affected with CMV infection.Its low oral bioavailability hinders the passage from ingested milk towards the infant’s plasma, except in preterm babies and immediate neonatal period, which may show an increased intestinal permeability.

Several factors might affect the decision to use DHPG in a nursing mother. No information is available on the clinical use of DHPG during breastfeeding. Cytomegalovirus (CMV) can be transmitted to infants though breastmilk, with preterm and immunocompromised infants at greatest risk. No information is available on any changes in the risk of transmission if the mother is being treated with DHPG. Although the manufacturer recommends avoiding breastfeeding during DHPG use because of the risk of infant drug toxicity, neonates with CMV infections are often treated directly with DHPG. If the mother has a concurrent infection with HIV, breastfeeding is not recommended in the United States and other developed countries.