Is Hydroxyacyclovir Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Hydroxyacyclovir? Is Hydroxyacyclovir safe for nursing mother and child? Does Hydroxyacyclovir extracts into breast milk? Does Hydroxyacyclovir has any long term or short term side effects on infants? Can Hydroxyacyclovir influence milk supply or can Hydroxyacyclovir decrease milk supply in lactating mothers?

Synthetic nucleoside which is analogue of guanine, structurally very closed related to acyclovir.Indicated for the treatment and prevention of Cytomegalovirus (CMV) in immunocompromised patients. At latest update no published data on excretion into breast milk were found. It is used in newborns and premature who are affected with CMV infection.Its low oral bioavailability hinders the passage from ingested milk towards the infant’s plasma, except in preterm babies and immediate neonatal period, which may show an increased intestinal permeability.

Several factors might affect the decision to use Hydroxyacyclovir in a nursing mother. No information is available on the clinical use of Hydroxyacyclovir during breastfeeding. Cytomegalovirus (CMV) can be transmitted to infants though breastmilk, with preterm and immunocompromised infants at greatest risk. No information is available on any changes in the risk of transmission if the mother is being treated with Hydroxyacyclovir. Although the manufacturer recommends avoiding breastfeeding during Hydroxyacyclovir use because of the risk of infant drug toxicity, neonates with CMV infections are often treated directly with Hydroxyacyclovir. If the mother has a concurrent infection with HIV, breastfeeding is not recommended in the United States and other developed countries.