Is DU-23000 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use DU-23000? Is DU-23000 safe for nursing mother and child? Does DU-23000 extracts into breast milk? Does DU-23000 has any long term or short term side effects on infants? Can DU-23000 influence milk supply or can DU-23000 decrease milk supply in lactating mothers?
DU-23000 lactation summary
- DrLact safety Score for DU-23000 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of DU-23000 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that DU-23000 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of DU-23000 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About DU-23000 usage in lactation
It is excreted into breast milk in non-significant amount. Plasma level in infants from mother who receive Fluvoxamine is usually undetectable. Not effects on the infant's physical and psychomotor development at both short or long-term were found. Because there is less experience published than with other antidepressants of the same pharmacological group, it should be preferred the use of an alternative drug that is known to be safer in the neonatal period or prematurity. Galactorrhea has been observed but less frequently than with other antidepressants. In cases of treatment with xanthines (theophylline, caffeine) for apnea of prematurity, the plasma level of them should be monitored because Fluvoxamine is a strong inhibitor of activity of the Cytochrome P450-CYP1A2 which is responsible for metabolic elimination of xanthines. Women who use antidepressant medication during pregnancy are in need of more support for breastfeeding since they are at risk for early weaning.