Question

I am a breastfeeding mother and i want to know if it is safe to use SCH 900222? Is SCH 900222 safe for nursing mother and child? Does SCH 900222 extracts into breast milk? Does SCH 900222 has any long term or short term side effects on infants? Can SCH 900222 influence milk supply or can SCH 900222 decrease milk supply in lactating mothers?

Answer by DrLact: About SCH 900222 usage in lactation

No information is available on the clinical use of SCH 900222 during breastfeeding. Because SCH 900222 is a large protein molecule with a molecular weight of 147,000, absorption by the infant is unlikely after the first few weeks postpartum, and it will probably be destroyed in the infant's gastrointestinal tract. Until more data become available, SCH 900222 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. SCH 900222 is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.

Synonyms of SCH 900222

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