Question

I am a breastfeeding mother and i want to know if it is safe to use MK-3222? Is MK-3222 safe for nursing mother and child? Does MK-3222 extracts into breast milk? Does MK-3222 has any long term or short term side effects on infants? Can MK-3222 influence milk supply or can MK-3222 decrease milk supply in lactating mothers?

Answer by DrLact: About MK-3222 usage in lactation

No information is available on the clinical use of MK-3222 during breastfeeding. Because MK-3222 is a large protein molecule with a molecular weight of 147,000, absorption by the infant is unlikely after the first few weeks postpartum, and it will probably be destroyed in the infant's gastrointestinal tract. Until more data become available, MK-3222 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. MK-3222 is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.

Synonyms of MK-3222

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