Is HSDB 8205 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use HSDB 8205? Is HSDB 8205 safe for nursing mother and child? Does HSDB 8205 extracts into breast milk? Does HSDB 8205 has any long term or short term side effects on infants? Can HSDB 8205 influence milk supply or can HSDB 8205 decrease milk supply in lactating mothers?
HSDB 8205 lactation summary
- DrLact safety Score for HSDB 8205 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of HSDB 8205 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that HSDB 8205 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of HSDB 8205 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using HSDB 8205 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About HSDB 8205 usage in lactation
Glucagon-like peptide 1 analogue that stimulates endogenous insulin secretion. Used to treat obesity and type 2 diabetes in combination with other oral antidiabetics, especially metformin. Administered subcutaneously. The most common side effects are nausea, vomiting and diarrhea. Low risk of hypoglycemia in monotherapy. Since the last update we have not found published data on its excretion in breast milk. Its pharmacokinetic data (high molecular weight and high percentage of plasma protein binding) make it very unlikely that significant amounts will pass into breast milk (Serrano 2014). Due to its protein nature, it deteriorates in the gastrointestinal tract, not being absorbed (Serrano 2014). This low oral bioavailability would make it difficult for it to pass to the infant’s plasma ingesting breast milk, except in preterm infants and in the immediate neonatal period when there may be increased intestinal permeability. Diet, exercise, and breastfeeding improve blood sugar levels.
Answer by DrLact: About HSDB 8205 usage in lactation
No information is available on the clinical use of HSDB 8205 during breastfeeding. Because HSDB 8205 is a large peptide molecule with a molecular weight of 3751 daltons, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, HSDB 8205 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.
Alternate Drugs
Liraglutide(Low Risk)
Dulaglutide(Low Risk)
Liraglutide(Low Risk)
Dulaglutide(Low Risk)
Metformin(Safe)
Alogliptin(Low Risk)
Insulin(Safe)
Glyburide(Safe)
Glipizide(Safe)
Linagliptin(Low Risk)
Glimepiride(Unsafe)
Chlorpropamide(Low Risk)
Sitagliptin(Low Risk)
Liraglutide(Low Risk)
Acetohexamide(Low Risk)
Acarbose(Safe)
Saxagliptin(Low Risk)
Colesevelam(Safe)
Miglitol(Safe)
Tolbutamide(Safe)
Rosiglitazone(Low Risk)
Repaglinide(Unsafe)
Empagliflozin(Unsafe)
Dulaglutide(Low Risk)
Pioglitazone(Low Risk)
Dapagliflozin(Unsafe)
Nateglinide(Unsafe)
Linagliptin(Low Risk)
Sitagliptin(Low Risk)
Liraglutide(Low Risk)
Saxagliptin(Low Risk)
Dulaglutide(Low Risk)
Alogliptin(Low Risk)