Is HSDB 8283 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use HSDB 8283? Is HSDB 8283 safe for nursing mother and child? Does HSDB 8283 extracts into breast milk? Does HSDB 8283 has any long term or short term side effects on infants? Can HSDB 8283 influence milk supply or can HSDB 8283 decrease milk supply in lactating mothers?
HSDB 8283 lactation summary
- DrLact safety Score for HSDB 8283 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of HSDB 8283 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that HSDB 8283 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of HSDB 8283 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using HSDB 8283 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About HSDB 8283 usage in lactation
Long-acting agonist of the glucagon-like peptide receptor type 1 (GLP-1) that stimulates the endogenous secretion of insulin and decreases that of glucagon.Used in type 2 diabetes in combination with other oral anti-diabetics, especially metformin. Subcutaneous administration once a week. There is risk of hypoglycaemia even in monotherapy. Since the last update, we have not found published data on its excretion in breast milk. Its pharmacokinetic data (very high molecular weight) make it very unlikely that it will be transferred to milk in significant quantities (Serrano 2014). Due to its protein nature, it is inactivated in the gastrointestinal tract, not being absorbed, so its oral bioavailability is practically nil (Serrano 2014), except in premature babies and immediate neonatal period when there may be greater intestinal permeability. Diet, exercise and breastfeeding improve blood glucose levels.
Answer by DrLact: About HSDB 8283 usage in lactation
No information is available on the clinical use of HSDB 8283 during breastfeeding. Because HSDB 8283 is a large protein molecule with a molecular weight of 59,669 daltons, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, HSDB 8283 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.
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