Is MEK162 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use MEK162? Is MEK162 safe for nursing mother and child? Does MEK162 extracts into breast milk? Does MEK162 has any long term or short term side effects on infants? Can MEK162 influence milk supply or can MEK162 decrease milk supply in lactating mothers?

No information is available on the clinical use of MEK162 during breastfeeding. Because MEK162 is 97% bound to plasma proteins, and the half-life of the drugis 3.5 hours, the amount in milk is likely to be low. However, the manufacturer recommends that breastfeeding be discontinued during MEK162 therapy and for at least 3 days after the final dose. For patients taking the combination with encorafenib, the manufacturer recommends that breastfeeding be discontinued during MEK162 therapy and for at least 2 weeks after the final dose.