Question

I am a breastfeeding mother and i want to know if it is safe to use KW 0761? Is KW 0761 safe for nursing mother and child? Does KW 0761 extracts into breast milk? Does KW 0761 has any long term or short term side effects on infants? Can KW 0761 influence milk supply or can KW 0761 decrease milk supply in lactating mothers?

Answer by DrLact: About KW 0761 usage in lactation

No information is available on the passage of KW 0761 into breastmilk. Because KW 0761 is a large protein molecule with a molecular weight of 149,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, KW 0761 injection should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. KW 0761 is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.
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