Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-YI437801BE? Is UNII-YI437801BE safe for nursing mother and child? Does UNII-YI437801BE extracts into breast milk? Does UNII-YI437801BE has any long term or short term side effects on infants? Can UNII-YI437801BE influence milk supply or can UNII-YI437801BE decrease milk supply in lactating mothers?

Answer by DrLact: About UNII-YI437801BE usage in lactation

No information is available on the passage of UNII-YI437801BE into breastmilk. Because UNII-YI437801BE is a large protein molecule with a molecular weight of 149,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, UNII-YI437801BE injection should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. UNII-YI437801BE is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.
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