Is Actinomycin I(sub 1) Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Actinomycin I(sub 1)? Is Actinomycin I(sub 1) safe for nursing mother and child? Does Actinomycin I(sub 1) extracts into breast milk? Does Actinomycin I(sub 1) has any long term or short term side effects on infants? Can Actinomycin I(sub 1) influence milk supply or can Actinomycin I(sub 1) decrease milk supply in lactating mothers?
Actinomycin I(sub 1) lactation summary
- DrLact safety Score for Actinomycin I(sub 1) is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of Actinomycin I(sub 1) may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that Actinomycin I(sub 1) may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using Actinomycin I(sub 1) .
- Usage of Actinomycin I(sub 1) is in contradiction to breastfeeding hence if it is must to use Actinomycin I(sub 1) and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Actinomycin I(sub 1) usage in lactation
Drug is cleared from the body in 7 elimination half-lives. Resuming breastfeeding is likely safe after 10 days of pumping-and-dumping.
Answer by DrLact: About Actinomycin I(sub 1) usage in lactation
No information is available on the use of Actinomycin I(sub 1) during breastfeeding. Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy. The manufacturer recommends that breastfeeding be discontinued during Actinomycin I(sub 1) therapy and for 14 days after the last dose.
Alternate Drugs
Bleomycin(Dangerous)
Doxorubicin(Dangerous)
Dactinomycin(Dangerous)
Alemtuzumab(Low Risk)
Vinblastine(Dangerous)
Etoposide(Dangerous)
Docetaxel(Dangerous)
Rituximab(Low Risk)
Pazopanib(Unsafe)
Bleomycin(Dangerous)
Doxorubicin(Dangerous)
Bevacizumab(Low Risk)
Vinorelbine(Dangerous)
Cyclophosphamide(Dangerous)
Dacarbazine(Dangerous)
Cisplatin(Unsafe)
Trastuzumab(Unsafe)
Busulfan(Dangerous)
Imatinib(Unsafe)
Erlotinib(Unsafe)
Thioguanine(Dangerous)
Cladribine(Dangerous)
Letrozole(Dangerous)
Exemestane(Dangerous)
Azelaic Acid(Safe)
Dasatinib(Unsafe)
Dactinomycin(Dangerous)
Nilotinib(Unsafe)
Vincristine(Dangerous)
Ipilimumab(Unsafe)
Tamoxifen(Dangerous)
Cetuximab(Unsafe)
Mitoxantrone(Dangerous)
Carboplatin(Dangerous)
Mercaptopurine(Safe)
Gemcitabine(Dangerous)
Paclitaxel(Dangerous)
Fluorouracil(Dangerous)
Nivolumab(Unsafe)
Hydroxyurea(Low Risk)
Dactinomycin(Dangerous)
Fusidic Acid(Safe)
Dactinomycin(Dangerous)