I am a breastfeeding mother and i want to know if it is safe to use DX-2930? Is DX-2930 safe for nursing mother and child? Does DX-2930 extracts into breast milk? Does DX-2930 has any long term or short term side effects on infants? Can DX-2930 influence milk supply or can DX-2930 decrease milk supply in lactating mothers?
No information is available on the clinical use of DX-2930 during breastfeeding. Because DX-2930 is a large protein molecule with a molecular weight of about 146,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. If DX-2930 is required by the mother, it is not a reason to discontinue breastfeeding. Until more data become available, DX-2930 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. DX-2930 is a human immunoglobulin G1 (IgG1) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G in mature milk by 60 to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.
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