Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-2372V1TKXK? Is UNII-2372V1TKXK safe for nursing mother and child? Does UNII-2372V1TKXK extracts into breast milk? Does UNII-2372V1TKXK has any long term or short term side effects on infants? Can UNII-2372V1TKXK influence milk supply or can UNII-2372V1TKXK decrease milk supply in lactating mothers?

Answer by DrLact: About UNII-2372V1TKXK usage in lactation

No information is available on the clinical use of UNII-2372V1TKXK during breastfeeding. Because UNII-2372V1TKXK is a large protein molecule with a molecular weight of about 146,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. If UNII-2372V1TKXK is required by the mother, it is not a reason to discontinue breastfeeding. Until more data become available, UNII-2372V1TKXK should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. UNII-2372V1TKXK is a human immunoglobulin G1 (IgG1) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G in mature milk by 60 to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.
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