Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-09Q5UV3747? Is UNII-09Q5UV3747 safe for nursing mother and child? Does UNII-09Q5UV3747 extracts into breast milk? Does UNII-09Q5UV3747 has any long term or short term side effects on infants? Can UNII-09Q5UV3747 influence milk supply or can UNII-09Q5UV3747 decrease milk supply in lactating mothers?

Answer by DrLact: About UNII-09Q5UV3747 usage in lactation

UNII-09Q5UV3747 acetate is available in the United States in a combination contraceptive vaginal ring (Annovera) that releases UNII-09Q5UV3747 acetate and ethinyl estradiol. No information is available on the use of this product during breastfeeding; however, UNII-09Q5UV3747 is poorly bioavailable orally, so systemic exposure to UNII-09Q5UV3747 in breastfed infants will be minimal. Based on the available evidence, expert opinion in the United States holds that because of the clotting risk, combination contraceptive products should not be used before 3 weeks postpartum. Between 3 weeks and 6 months postpartum, the advantages of using the method generally outweigh the theoretical or proven risks, although the evidence of lack of effect on lactation is poor and does not include preterm or ill infants. After 6 months postpartum, combination contraceptives, including oral tablets, the transdermal patch and vaginal ring, can be used, but progestin-only methods are preferred if breastfeeding will be continued.[1] World Health Organization guidelines are more restrictive, stating that combined oral contraceptives should not be used in nursing mothers before 42 days postpartum and the disadvantages of using the method generally outweigh the advantages between 6 weeks and 6 months postpartum.[2] The manufacturer of Annovera recommends that another form of contraception should be used until breastfeeding is discontinued.

UNII-09Q5UV3747 Side Effects in Breastfeeding

Relevant published information on UNII-09Q5UV3747 acetate and ethinylestradiol vaginal insert was not found as of the revision date. Studies on the use of UNII-09Q5UV3747 acetate implants have found no adverse effects on growth and development.[4][5]
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