Is (S)-Topotecan Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use (S)-Topotecan? Is (S)-Topotecan safe for nursing mother and child? Does (S)-Topotecan extracts into breast milk? Does (S)-Topotecan has any long term or short term side effects on infants? Can (S)-Topotecan influence milk supply or can (S)-Topotecan decrease milk supply in lactating mothers?
Answer by DrLact: About (S)-Topotecan usage in lactation
Most sources consider breastfeeding to be contraindicated during maternal high-dose antineoplastic drug therapy. The manufacturer recommends that women not breastfeed during treatment with (S)-Topotecan and for 1 week after the last dose. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[1] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[2]
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