Question

I am a breastfeeding mother and i want to know if it is safe to use 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)-? Is 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)- safe for nursing mother and child? Does 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)- extracts into breast milk? Does 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)- has any long term or short term side effects on infants? Can 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)- influence milk supply or can 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)- decrease milk supply in lactating mothers?

Answer by DrLact: About 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)- usage in lactation

No information is available on the use of 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)- marboxil during breastfeeding. Because 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)- is 93% bound to plasma proteins, the amount in milk is likely to be low. The drug's half-life is 4 hours, so any drug in breastmilk should be gone in one day. If 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)- is required by the mother, it is not a reason to discontinue breastfeeding. However, because no information is available on the use of 1H-(1,4)Oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazine-6,8-dione, 12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)- breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Alternate Drugs

Indinavir(Unsafe)
Famciclovir(Low Risk)
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Zanamivir(Safe)
Efavirenz(Unsafe)
Velpatasvir(Low Risk)
Zidovudine(Low Risk)
Didanosine(Unsafe)
Simeprevir(Low Risk)
Sofosbuvir(Low Risk)
Tenofovir(Safe)
Ribavirin(Low Risk)
Valganciclovir(Low Risk)
Ledipasvir(Low Risk)
Ganciclovir(Low Risk)
Saquinavir(Unsafe)
Abacavir(Safe)
Ombitasvir(Low Risk)
Ritonavir(Unsafe)
Daclatasvir(Low Risk)
Nevirapine(Low Risk)
Dasabuvir(Low Risk)
Nelfinavir(Unsafe)
Amantadine(Low Risk)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Gemcitabine(Dangerous)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Orlistat(Low Risk)
Dasatinib(Unsafe)
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