Question

I am a breastfeeding mother and i want to know if it is safe to use VX 478? Is VX 478 safe for nursing mother and child? Does VX 478 extracts into breast milk? Does VX 478 has any long term or short term side effects on infants? Can VX 478 influence milk supply or can VX 478 decrease milk supply in lactating mothers?

VX 478 lactation summary

VX 478 is unsafe in breastfeeding
  • DrLact safety Score for VX 478 is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of VX 478 may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that VX 478 may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using VX 478 .
  • It is recommended to evaluate the advantage of not breastfeeding while using VX 478 Vs not using VX 478 And continue breastfeeding.
  • While using VX 478 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About VX 478 usage in lactation

Anti-HIV drug. No experience in young infants. Withdrawn from market. Mothers should be aware of HIV transmission through breast milk has been reported.

Alternate Drugs for Antivirals for systemic use. ATC J05

Acyclovir(Safe)
Famciclovir(Low Risk)
Abacavir(Safe)
Didanosine(Unsafe)
Efavirenz(Unsafe)
Indinavir(Unsafe)
Nelfinavir(Unsafe)
Nevirapine(Low Risk)
Ritonavir(Unsafe)
Saquinavir(Unsafe)
Tenofovir(Safe)
Zidovudine(Low Risk)
Zanamivir(Safe)
Ribavirin(Low Risk)
Dasabuvir(Low Risk)
Daclatasvir(Low Risk)
Ombitasvir(Low Risk)
Ledipasvir(Low Risk)
Sofosbuvir(Low Risk)
Simeprevir(Low Risk)
Velpatasvir(Low Risk)
Ganciclovir(Low Risk)
Valganciclovir(Low Risk)
Amprenavir(Unsafe)
Brivudine(Low Risk)
Cidofovir(Unsafe)
Foscarnet(Unsafe)
Lysozyme(Safe)
Zalcitabine(Unsafe)
Tribavirin(Low Risk)
Azidothymidine(Low Risk)
Azt(Low Risk)
Aciclovir(Safe)
BW-248U(Safe)
Ddi(Unsafe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.