Question

I am a breastfeeding mother and i want to know if it is safe to use Amoxapine? Is Amoxapine safe for nursing mother and child? Does Amoxapine extracts into breast milk? Does Amoxapine has any long term or short term side effects on infants? Can Amoxapine influence milk supply or can Amoxapine decrease milk supply in lactating mothers?

Amoxapine lactation summary

Amoxapine is safe in breastfeeding
  • DrLact safety Score for Amoxapine is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Amoxapine is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Amoxapine does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Amoxapine safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Amoxapine usage in lactation

Small amount is excreted into breast milk. No adverse effect has been observed in infants. Galactorrhea and oligomenorrhea have been reported in women.

Answer by DrLact: About Amoxapine usage in lactation

Because no information is available on the use of amoxapine during breastfeeding, another drug may be preferred, especially while nursing a newborn or preterm infant. If amoxapine is required by the mother, it is not a reason to discontinue breastfeeding. Exclusively breastfed infants should be monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.

Amoxapine Possible Effects in Breastfeeding

Two cases of galactorrhea have been reported in nonbreastfeeding women who were taking amoxapine.[1][2] The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed. An observational study looked at outcomes of 2859 women who took an antidepressant during the 2 years prior to pregnancy. Compared to women who did not take an antidepressant during pregnancy, mothers who took an antidepressant during all 3 trimesters of pregnancy were 37% less likely to be breastfeeding upon hospital discharge. Mothers who took an antidepressant only during the third trimester were 75% less likely to be breastfeeding at discharge. Those who took an antidepressant only during the first and second trimesters did not have a reduced likelihood of breastfeeding at discharge.[3] The antidepressants used by the mothers were not specified. A retrospective cohort study of hospital electronic medical records from 2001 to 2008 compared women who had been dispensed an antidepressant during late gestation (n = 575) to those who had a psychiatric illness but did not receive an antidepressant (n = 1552) and mothers who did not have a psychiatric diagnosis (n = 30,535). Women who received an antidepressant were 37% less likely to be breastfeeding at discharge than women without a psychiatric diagnosis, but no less likely to be breastfeeding than untreated mothers with a psychiatric diagnosis.[4] None of the mothers were taking amoxapine.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.