Is 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one? Is 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one safe for nursing mother and child? Does 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one extracts into breast milk? Does 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one has any long term or short term side effects on infants? Can 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one influence milk supply or can 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one decrease milk supply in lactating mothers?
2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one lactation summary
- DrLact safety Score for 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one usage in lactation
Produced through the fermentation of rice by fungus (e.g. Aspergillus, Penicillium, Acetobacter). Properties: antimicrobial activity, chelation of cupper with inhibition of Tyrosinase activity and lowering levels of Melanin. May have toxic effects (e.g. seizures, cancerogenic) when administered by mouth. Avoid using it over the breast or instead rinse the area thouroghly before nursing.
Alternate Drugs for Other Dermatological preparations. ATC D11
Pimecrolimus(Low Risk)
Aluminium Acetate(Safe)
Intralesional Bleomycin(Unsafe)
Diphencyprone(Safe)
Dihydroxyacetone(Low Risk)
Ellagic Acid(Safe)
Kojic Acid(Low Risk)
Minoxidil Topical Use(Safe)
Tacrolimus (topical use)(Safe)
Finasteride(Low Risk)