I am a breastfeeding mother and i want to know if it is safe to use Bretylium? Is Bretylium safe for nursing mother and child? Does Bretylium extracts into breast milk? Does Bretylium has any long term or short term side effects on infants? Can Bretylium influence milk supply or can Bretylium decrease milk supply in lactating mothers?
Because there is little published experience with bretylium during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant. It has low oral bioavailability, so older infants are unlikely to absorb it. Exclusively breastfed infants should be carefully monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.
A dose of 400 mg of bretylium tosylate every 8 hours was taken orally by one mother while nursing a newborn. She was also taking atenolol 25 mg daily, propranolol 20 mg three times a day, spironolactone 75 mg every other day and multivitamin, potassium and magnesium supplements. Jaundice, thought to be unrelated to the drug, occurred at 60 hours of age, but resolved. The infant had appropriate weight gain and development during the first 4 months of life.[1]
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