Is HSDB 7202 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use HSDB 7202? Is HSDB 7202 safe for nursing mother and child? Does HSDB 7202 extracts into breast milk? Does HSDB 7202 has any long term or short term side effects on infants? Can HSDB 7202 influence milk supply or can HSDB 7202 decrease milk supply in lactating mothers?

HSDB 7202 lactation summary

DrLact safety Score for HSDB 7202 is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of HSDB 7202 is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that HSDB 7202 does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of HSDB 7202 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About HSDB 7202 usage in lactation

It is a glycoprotein which is extracted from pineapple (Ananas comosus, Ananas sativos) and other fruits with a protease-like property (see specific info) and activity as proteolytic-like enzyme with the ability of protein digestion. It is used in the food industry to softening the meat.    In medicine no proven utility has been shown. Effectiveness as an anti-inflammatory and digestive-enhancer is dubious. It has been topically used on local inflammations and burns.   It has been proposed for oral treatment of breast plethora (Murata 1965), yet there has been an only isolated and very old study which does not constitute an enough evidence to widely recommend it (Snowden 2007, ABM 2016). The few studies on oral protease utilization to alleviate breast plethora found out discordant results wiht low levels of evidence (ABM 2016, Mangesi 2016).   At latest update no published data were found on its excretion into breastmilk. Because of a high molecular weight and a non-significant plasma level concentration (5 micrograms / L) the passage into breastmilk is seemingly unlikely.

Alternate Drugs for Phytotherapy, Systemic Use

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Chamomile(Safe)

Echinacea(Low Risk)

Alfalfa(Unsafe)

Dong Quai(Low Risk)

Cranberry(Safe)

Licorice(Unsafe)

Rhubarb(Low Risk)

Lavender(Low Risk)

Sweet Briar(Safe)

Barberry(Dangerous)

Carob(Safe)

Common Poppy(Unsafe)

Angelica(Unsafe)

Star Anise(Dangerous)

Mugwort(Unsafe)

Edible Burdock(Low Risk)

Box(Unsafe)

Boldo(Unsafe)

Bromelains(Safe)

Calaguala(Safe)

Caralluma(Low Risk)

Carrageen(Low Risk)

Horse Chestnut(Safe)

Blue-Cohosh(Dangerous)

Indian Pennywort(Safe)

Squisandra(Low Risk)

Prickly Pear(Safe)

Black-Cohosh(Unsafe)

Horsetail(Unsafe)

Colocynth Pulp(Dangerous)

Ergot Fungus(Dangerous)

Ephedra(Unsafe)

Steviol(Safe)

Eucalyptus(Unsafe)

Eyebright(Safe)

Flowers(Low Risk)

Fucus(Unsafe)

Goat´s Rue(Unsafe)

Bearberry(Unsafe)

Guarana(Low Risk)

Devil’s Claw Root(Low Risk)

Herniary(Low Risk)

St. John´s Wort(Safe)

Hyssop(Unsafe)

Syrup Of Ipecac(Low Risk)

Jin Bu Huan(Dangerous)

Kava Kava(Dangerous)

Clubmoss(Unsafe)

Maca(Safe)

Common gromwell(Unsafe)

Nux Vomica(Dangerous)

White Nettle(Safe)

Papain(Low Risk)

Passion Flower(Low Risk)

African Cherry(Dangerous)

Scots Pine(Unsafe)

Pycnogenol(Safe)

Pennyroyal(Unsafe)

Primrose(Safe)

Radish(Safe)

Ironwort(Low Risk)

Liquorice(Unsafe)

Rooibos(Safe)

Rose Hip(Safe)

French rose(Safe)

Butcher´s Broom(Safe)

Willow(Safe)

Soy(Low Risk)

Herbal Teas(Low Risk)

Rock Tea(Low Risk)

Lime Flower(Safe)

Tormentil(Safe)

Meadow-Sweet(Low Risk)

Golden Rod(Safe)

Sarsaparilla(Low Risk)

Sweet Flag(Unsafe)

Saw palmetto(Low Risk)

Common gum cistus(Low Risk)

Cat's Claw(Low Risk)

Milk Vetch(Low Risk)

Chinese angelica(Low Risk)

White Mulberry(Low Risk)

Di Huang(Low Risk)

Zi Wan(Unsafe)

Dang Shen(Low Risk)

Reishi(Low Risk)

glycyrrhizic acid(Unsafe)

Glycyrrhizin(Unsafe)

American cranberry(Safe)

Carrageenan(Low Risk)

Carrageenin(Low Risk)

Verbena officinalis(Low Risk)

Passion Vine(Low Risk)

Chaste Tree(Unsafe)

Plant Protease Concentrate(Safe)

Sweet Cane(Unsafe)

Sweet root(Unsafe)

Irish Moss(Low Risk)

Bromelain(Safe)

Bromelin(Safe)

Acorus calamus(Unsafe)

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.