Question

I am a breastfeeding mother and i want to know if it is safe to use Alfentanil? Is Alfentanil safe for nursing mother and child? Does Alfentanil extracts into breast milk? Does Alfentanil has any long term or short term side effects on infants? Can Alfentanil influence milk supply or can Alfentanil decrease milk supply in lactating mothers?

Alfentanil lactation summary

Alfentanil is safe in breastfeeding
  • DrLact safety Score for Alfentanil is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Alfentanil is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Alfentanil does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Alfentanil safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Alfentanil usage in lactation

Analgesic opioid used in anesthesic procedures with very low excretion into breast milk.

Answer by DrLact: About Alfentanil usage in lactation

When used epidurally or intravenously during labor or for a short time immediately postpartum, amounts of alfentanil ingested by the neonate are small and would not be expected to cause any adverse effects in breastfed infants. Alfentanil is highly protein bound which should result in less transfer to breastmilk than other opiates; however, because there is no published experience with repeated doses of intravenous alfentanil during established lactation, other agents may be preferred, especially while nursing a newborn or preterm infant. Once the mother's milk comes in, it is best to provide pain control with a nonnarcotic analgesic and limit maternal intake of alfentanil to a few days with careful monitoring. If the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties, or limpness, a physician should be contacted immediately. Labor pain medication may delay the onset of lactation.

Alfentanil Possible Effects in Breastfeeding

Narcotics can increase serum prolactin.[2][3] However, the prolactin level in a mother with established lactation may not affect her ability to breastfeed. A national survey of women and their infants from late pregnancy through 12 months postpartum compared the time of lactogenesis II in mothers who did and did not receive pain medication during labor. Categories of medication were spinal or epidural only, spinal or epidural plus another medication, and other pain medication only. Women who received medications from any of the categories had about twice the risk of having delayed lactogenesis II (>72 hours) compared to women who received no labor pain medication.[4]
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.