Is UNII-PA1123N395 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-PA1123N395? Is UNII-PA1123N395 safe for nursing mother and child? Does UNII-PA1123N395 extracts into breast milk? Does UNII-PA1123N395 has any long term or short term side effects on infants? Can UNII-PA1123N395 influence milk supply or can UNII-PA1123N395 decrease milk supply in lactating mothers?
UNII-PA1123N395 lactation summary
- DrLact safety Score for UNII-PA1123N395 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of UNII-PA1123N395 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that UNII-PA1123N395 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of UNII-PA1123N395 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using UNII-PA1123N395 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-PA1123N395 usage in lactation
It is a second-generation antihistamine drug without sedative or antimuscarinic effects (AEMPS 2016, Wolthers 2013, Scaglione 2012, Conen 2011, Church 2011). At latest update, relevant data on its excretion into breast milk were not found. Due to a lack of sedative effect since it does not break through the blood-brain barrier (Scaglione 2012, Church 2011), and, a favorable pharmacokinetic profile (Togawa 2016, AEMPS 2016, Sádaba 2013), -high protein-binding capacity, and a medium oral bioavailability-, the risk for problems in the nursing infant is very low. However, until more and reliable data on this drug concerning breastfeeding is available, known safer options should be preferred, especially for breastfeeding mothers in the first month after birth or in case of prematurity.
Alternate Drugs for Antihistamines for systemic use. ATC R06A.
Acrivastine(Low Risk)
Brompheniramine(Low Risk)
Carbinoxamine(Low Risk)
Cetirizine(Safe)
Chlorpheniramine(Low Risk)
Clemastine(Low Risk)
Desloratadine(Safe)
Dexchlorpheniramine(Low Risk)
Dimenhydrinate(Low Risk)
Diphenhydramine(Low Risk)
Fexofenadine(Safe)
Hydroxyzine(Safe)
Loratadine(Safe)
Promethazine(Low Risk)
Pyrilamine(Low Risk)
Thiethylperazine(Unsafe)
Triprolidine(Safe)
Epinastine(Low Risk)
Meclizine(Low Risk)
Ketotifen(Low Risk)
Levocetirizine(Low Risk)
Cyclizine(Low Risk)
Doxylamine(Unsafe)
Cetirizine Hydrochloride(Safe)
Alimemazine(Low Risk)
Astemizole(Unsafe)
Azatadine Maleate(Low Risk)
Bilastine(Low Risk)
Brompheniramine Maleate(Low Risk)
Buclizine-Hcl(Low Risk)
Carbinoxamine Maleate(Low Risk)
Cyproheptadine-Hcl(Low Risk)
Clemastine Fumarate(Low Risk)
Chlorcyclizine(Low Risk)
Chlorphenamine(Low Risk)
Chloropyramine Hydrochloride(Unsafe)
Ebastine(Low Risk)
Ketotifen Fumarate(Low Risk)
Meclozine(Low Risk)
Mepyramine(Low Risk)
Mequitazine(Unsafe)
Mizolastine(Low Risk)
Pizotifen(Low Risk)
Rupatadine Fumarate(Low Risk)
Terfenadine(Low Risk)
Trimeprazine(Low Risk)
Halopyramine Hydrochloride(Unsafe)
Doxylamine Succinate(Unsafe)
Dramamine Ii(Low Risk)
Chlorpheniramine Maleate(Low Risk)
Pizotyline(Low Risk)
Benzhydramine(Low Risk)
Promethazine Hydrochloride(Low Risk)
Pyranisamine(Low Risk)
Kelp(Unsafe)