Is EINECS 222-498-0 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use EINECS 222-498-0? Is EINECS 222-498-0 safe for nursing mother and child? Does EINECS 222-498-0 extracts into breast milk? Does EINECS 222-498-0 has any long term or short term side effects on infants? Can EINECS 222-498-0 influence milk supply or can EINECS 222-498-0 decrease milk supply in lactating mothers?

It is a first generation antihistaminic and ethanolamine drug with a markedly sedative and antimuscarinic effect (may inhibit lactation). When associated to phenylephrine it is used for nasal congestion relief. Use a minimal dose. Avoid a long-term use.

Small occasional doses of carbinoxamine are probably acceptable during breastfeeding. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

There are no reports of infants breastfed during maternal therapy with carbinoxamine. In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[1]

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of carbinoxamine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.