Is Carboxyterfenadine hydrochloride Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Carboxyterfenadine hydrochloride? Is Carboxyterfenadine hydrochloride safe for nursing mother and child? Does Carboxyterfenadine hydrochloride extracts into breast milk? Does Carboxyterfenadine hydrochloride has any long term or short term side effects on infants? Can Carboxyterfenadine hydrochloride influence milk supply or can Carboxyterfenadine hydrochloride decrease milk supply in lactating mothers?

Antihistamine drug of 2nd generation, piperidine derivative, which is an active metabolite of Terfenadine with minimal sedative effect. Oral administration twice a day. It is excreted into breast milk in clinically non-significant amount (Butler 2014, So 2010, Leachman 2006, Lucas 1995). On a telephone interview, 10% of infants whose mothers were on terfenadine, recognized to have experienced colicky pain and hyperexcitability that disappeared without treatment (Ito 1993). American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).

Because of its lack of sedation and low milk levels, maternal use of fexofenadine would not be expected to cause any adverse effects in breastfed infants. Fexofenadine might have a negative effect on lactation, especially in combination with a sympathomimetic agent such as pseudoephedrine.

In one telephone follow-up study of 25 infants exposed to the fexofenadine's parent drug terfenadine, 3 mothers reported irritability in their infants. None of the reactions required medical attention.[2]

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.