Is Terfenadine carboxylate hydrochloride Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Terfenadine carboxylate hydrochloride? Is Terfenadine carboxylate hydrochloride safe for nursing mother and child? Does Terfenadine carboxylate hydrochloride extracts into breast milk? Does Terfenadine carboxylate hydrochloride has any long term or short term side effects on infants? Can Terfenadine carboxylate hydrochloride influence milk supply or can Terfenadine carboxylate hydrochloride decrease milk supply in lactating mothers?
Terfenadine carboxylate hydrochloride lactation summary
- DrLact safety Score for Terfenadine carboxylate hydrochloride is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Terfenadine carboxylate hydrochloride is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Terfenadine carboxylate hydrochloride does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Terfenadine carboxylate hydrochloride safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Terfenadine carboxylate hydrochloride usage in lactation
Antihistamine drug of 2nd generation, piperidine derivative, which is an active metabolite of Terfenadine with minimal sedative effect. Oral administration twice a day. It is excreted into breast milk in clinically non-significant amount (Butler 2014, So 2010, Leachman 2006, Lucas 1995). On a telephone interview, 10% of infants whose mothers were on terfenadine, recognized to have experienced colicky pain and hyperexcitability that disappeared without treatment (Ito 1993). American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).
Answer by DrLact: About Terfenadine carboxylate hydrochloride usage in lactation
Because of its lack of sedation and low milk levels, maternal use of fexofenadine would not be expected to cause any adverse effects in breastfed infants. Fexofenadine might have a negative effect on lactation, especially in combination with a sympathomimetic agent such as pseudoephedrine.
Terfenadine carboxylate hydrochloride Side Effects in Breastfeeding
In one telephone follow-up study of 25 infants exposed to the fexofenadine's parent drug terfenadine, 3 mothers reported irritability in their infants. None of the reactions required medical attention.[2]
Terfenadine carboxylate hydrochloride Possible Effects in Breastfeeding
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs for Antihistamines for systemic use. ATC R06A.
Acrivastine(Low Risk)
Brompheniramine(Low Risk)
Carbinoxamine(Low Risk)
Cetirizine(Safe)
Chlorpheniramine(Low Risk)
Clemastine(Low Risk)
Desloratadine(Safe)
Dexchlorpheniramine(Low Risk)
Dimenhydrinate(Low Risk)
Diphenhydramine(Low Risk)
Fexofenadine(Safe)
Hydroxyzine(Safe)
Loratadine(Safe)
Promethazine(Low Risk)
Pyrilamine(Low Risk)
Thiethylperazine(Unsafe)
Triprolidine(Safe)
Epinastine(Low Risk)
Meclizine(Low Risk)
Ketotifen(Low Risk)
Levocetirizine(Low Risk)
Cyclizine(Low Risk)
Doxylamine(Unsafe)
Cetirizine Hydrochloride(Safe)
Alimemazine(Low Risk)
Astemizole(Unsafe)
Azatadine Maleate(Low Risk)
Bilastine(Low Risk)
Brompheniramine Maleate(Low Risk)
Buclizine-Hcl(Low Risk)
Carbinoxamine Maleate(Low Risk)
Cyproheptadine-Hcl(Low Risk)
Clemastine Fumarate(Low Risk)
Chlorcyclizine(Low Risk)
Chlorphenamine(Low Risk)
Chloropyramine Hydrochloride(Unsafe)
Ebastine(Low Risk)
Ketotifen Fumarate(Low Risk)
Meclozine(Low Risk)
Mepyramine(Low Risk)
Mequitazine(Unsafe)
Mizolastine(Low Risk)
Pizotifen(Low Risk)
Rupatadine Fumarate(Low Risk)
Terfenadine(Low Risk)
Trimeprazine(Low Risk)
Halopyramine Hydrochloride(Unsafe)
Doxylamine Succinate(Unsafe)
Dramamine Ii(Low Risk)
Chlorpheniramine Maleate(Low Risk)
Pizotyline(Low Risk)
Benzhydramine(Low Risk)
Promethazine Hydrochloride(Low Risk)
Pyranisamine(Low Risk)
Kelp(Unsafe)