Is UR-12592 fumarate Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UR-12592 fumarate? Is UR-12592 fumarate safe for nursing mother and child? Does UR-12592 fumarate extracts into breast milk? Does UR-12592 fumarate has any long term or short term side effects on infants? Can UR-12592 fumarate influence milk supply or can UR-12592 fumarate decrease milk supply in lactating mothers?
UR-12592 fumarate lactation summary
- DrLact safety Score for UR-12592 fumarate is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of UR-12592 fumarate may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that UR-12592 fumarate may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of UR-12592 fumarate low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using UR-12592 fumarate We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UR-12592 fumarate usage in lactation
Second generation antihistamine and piperidine-type compound, without the sedative and anticholinergic effects of first generation antihistaminics. Pharmacokinetic data (moderately high molecular weight and high percentage of protein binding) make it unlikely an excretion into breast milk in significant amounts. Until more published data on this drug regarding breastfeeding is available, safer alternatives of better known drugs should be preferable, especially during the neonatal period and in case of prematurity. Follow-up the baby for drowsiness and inappropriate infant feeding.
Alternate Drugs for Antihistamines for systemic use. ATC R06A.
Acrivastine(Low Risk)
Brompheniramine(Low Risk)
Carbinoxamine(Low Risk)
Cetirizine(Safe)
Chlorpheniramine(Low Risk)
Clemastine(Low Risk)
Desloratadine(Safe)
Dexchlorpheniramine(Low Risk)
Dimenhydrinate(Low Risk)
Diphenhydramine(Low Risk)
Fexofenadine(Safe)
Hydroxyzine(Safe)
Loratadine(Safe)
Promethazine(Low Risk)
Pyrilamine(Low Risk)
Thiethylperazine(Unsafe)
Triprolidine(Safe)
Epinastine(Low Risk)
Meclizine(Low Risk)
Ketotifen(Low Risk)
Levocetirizine(Low Risk)
Cyclizine(Low Risk)
Doxylamine(Unsafe)
Cetirizine Hydrochloride(Safe)
Alimemazine(Low Risk)
Astemizole(Unsafe)
Azatadine Maleate(Low Risk)
Bilastine(Low Risk)
Brompheniramine Maleate(Low Risk)
Buclizine-Hcl(Low Risk)
Carbinoxamine Maleate(Low Risk)
Cyproheptadine-Hcl(Low Risk)
Clemastine Fumarate(Low Risk)
Chlorcyclizine(Low Risk)
Chlorphenamine(Low Risk)
Chloropyramine Hydrochloride(Unsafe)
Ebastine(Low Risk)
Ketotifen Fumarate(Low Risk)
Meclozine(Low Risk)
Mepyramine(Low Risk)
Mequitazine(Unsafe)
Mizolastine(Low Risk)
Pizotifen(Low Risk)
Rupatadine Fumarate(Low Risk)
Terfenadine(Low Risk)
Trimeprazine(Low Risk)
Halopyramine Hydrochloride(Unsafe)
Doxylamine Succinate(Unsafe)
Dramamine Ii(Low Risk)
Chlorpheniramine Maleate(Low Risk)
Pizotyline(Low Risk)
Benzhydramine(Low Risk)
Promethazine Hydrochloride(Low Risk)
Pyranisamine(Low Risk)
Kelp(Unsafe)