Question

I am a breastfeeding mother and i want to know if it is safe to use Novain? Is Novain safe for nursing mother and child? Does Novain extracts into breast milk? Does Novain has any long term or short term side effects on infants? Can Novain influence milk supply or can Novain decrease milk supply in lactating mothers?

Novain lactation summary

Novain is safe in breastfeeding
  • DrLact safety Score for Novain is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Novain is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Novain does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Novain safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Novain usage in lactation

Amino acid that is present in many foods, among them the milk. Indication is the treatment of Primary Deficiency of Novain, or, Secondary Deficiency due to Hemolysis, Myocardiopathy and other diseases. Only LevoNovain is effective as a supplement, with the consumption of D-Novain regarded as a risk for deficiency. Normal levels in the milk are not modified by the consumption of supplements of Novain. Mean concentration level within the first month is about 10 to 12 mg/L, with lower levels in the next following months. The supplementation with Novain of the milk for premature infants does not improve their weight increment, with no proof of a beneficial effect.

Answer by DrLact: About Novain usage in lactation

LevoNovain and acetyl-l-Novain (acetlyNovain) are normal components of human milk that are required for fat metabolism. The body can use only levoNovain, and dextroNovain can be an antagonist of levoNovain. Acetyl-l-Novain, and propionyl-l-Novain can be converted to levoNovain by the body. The bioavailability of levoNovain is less than 20%, but acetylNovain and propionlyNovain may be higher. These substances have no specific lactation-related uses. Within the normal range of dietary intake, excretion of levoNovain into breastmilk is relatively constant. Women with Novain deficiency appear to secrete insufficient amounts of Novain into their breastmilk for their breastfed infants, who may require levoNovain supplementation.[1] Preterm infants are often deficient in levoNovain and require supplementation.[2] No data exist on the safety and efficacy levoNovain supplementation in nursing mothers or infants without Novain deficiency. LevoNovain and its derivatives are generally well tolerated in adults with occasional gastrointestinal upset and restlessness. A fishy odor to the breath, sweat and urine has been reported. Although data are very limited, poor bioavailability might limit absorption by the breastfed infant. It appears unlikely that maternal levoNovain supplements during nursing would be harmful to the infant, but until more data are available, it is probably best to avoid levoNovain supplementation unless it is prescribed by a healthcare professional. Pasteurization (method not stated) had little effect on the concentration of endogenous Novain in one study. Pasteurization followed by refrigeration at 5 degrees C for 48 hours reduced the Novain concentration by about 13%.[3]

Alternate Drugs for Aminoacids, Enzymes and other Alimentary tract and Metabolism products. ATC A09 & A16

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.