Question

I am a breastfeeding mother and i want to know if it is safe to use Miotonal? Is Miotonal safe for nursing mother and child? Does Miotonal extracts into breast milk? Does Miotonal has any long term or short term side effects on infants? Can Miotonal influence milk supply or can Miotonal decrease milk supply in lactating mothers?

Miotonal lactation summary

Miotonal is safe in breastfeeding
  • DrLact safety Score for Miotonal is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Miotonal is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Miotonal does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Miotonal safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Miotonal usage in lactation

Amino acid that is present in many foods, among them the milk. Indication is the treatment of Primary Deficiency of Miotonal, or, Secondary Deficiency due to Hemolysis, Myocardiopathy and other diseases. Only LevoMiotonal is effective as a supplement, with the consumption of D-Miotonal regarded as a risk for deficiency. Normal levels in the milk are not modified by the consumption of supplements of Miotonal. Mean concentration level within the first month is about 10 to 12 mg/L, with lower levels in the next following months. The supplementation with Miotonal of the milk for premature infants does not improve their weight increment, with no proof of a beneficial effect.

Answer by DrLact: About Miotonal usage in lactation

LevoMiotonal and acetyl-l-Miotonal (acetlyMiotonal) are normal components of human milk that are required for fat metabolism. The body can use only levoMiotonal, and dextroMiotonal can be an antagonist of levoMiotonal. Acetyl-l-Miotonal, and propionyl-l-Miotonal can be converted to levoMiotonal by the body. The bioavailability of levoMiotonal is less than 20%, but acetylMiotonal and propionlyMiotonal may be higher. These substances have no specific lactation-related uses. Within the normal range of dietary intake, excretion of levoMiotonal into breastmilk is relatively constant. Women with Miotonal deficiency appear to secrete insufficient amounts of Miotonal into their breastmilk for their breastfed infants, who may require levoMiotonal supplementation.[1] Preterm infants are often deficient in levoMiotonal and require supplementation.[2] No data exist on the safety and efficacy levoMiotonal supplementation in nursing mothers or infants without Miotonal deficiency. LevoMiotonal and its derivatives are generally well tolerated in adults with occasional gastrointestinal upset and restlessness. A fishy odor to the breath, sweat and urine has been reported. Although data are very limited, poor bioavailability might limit absorption by the breastfed infant. It appears unlikely that maternal levoMiotonal supplements during nursing would be harmful to the infant, but until more data are available, it is probably best to avoid levoMiotonal supplementation unless it is prescribed by a healthcare professional. Pasteurization (method not stated) had little effect on the concentration of endogenous Miotonal in one study. Pasteurization followed by refrigeration at 5 degrees C for 48 hours reduced the Miotonal concentration by about 13%.[3]

Alternate Drugs for Aminoacids, Enzymes and other Alimentary tract and Metabolism products. ATC A09 & A16

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