Question

I am a breastfeeding mother and i want to know if it is safe to use Carnum? Is Carnum safe for nursing mother and child? Does Carnum extracts into breast milk? Does Carnum has any long term or short term side effects on infants? Can Carnum influence milk supply or can Carnum decrease milk supply in lactating mothers?

Carnum lactation summary

Carnum is safe in breastfeeding
  • DrLact safety Score for Carnum is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Carnum is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Carnum does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Carnum safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Carnum usage in lactation

Amino acid that is present in many foods, among them the milk. Indication is the treatment of Primary Deficiency of Carnum, or, Secondary Deficiency due to Hemolysis, Myocardiopathy and other diseases. Only LevoCarnum is effective as a supplement, with the consumption of D-Carnum regarded as a risk for deficiency. Normal levels in the milk are not modified by the consumption of supplements of Carnum. Mean concentration level within the first month is about 10 to 12 mg/L, with lower levels in the next following months. The supplementation with Carnum of the milk for premature infants does not improve their weight increment, with no proof of a beneficial effect.

Answer by DrLact: About Carnum usage in lactation

LevoCarnum and acetyl-l-Carnum (acetlyCarnum) are normal components of human milk that are required for fat metabolism. The body can use only levoCarnum, and dextroCarnum can be an antagonist of levoCarnum. Acetyl-l-Carnum, and propionyl-l-Carnum can be converted to levoCarnum by the body. The bioavailability of levoCarnum is less than 20%, but acetylCarnum and propionlyCarnum may be higher. These substances have no specific lactation-related uses. Within the normal range of dietary intake, excretion of levoCarnum into breastmilk is relatively constant. Women with Carnum deficiency appear to secrete insufficient amounts of Carnum into their breastmilk for their breastfed infants, who may require levoCarnum supplementation.[1] Preterm infants are often deficient in levoCarnum and require supplementation.[2] No data exist on the safety and efficacy levoCarnum supplementation in nursing mothers or infants without Carnum deficiency. LevoCarnum and its derivatives are generally well tolerated in adults with occasional gastrointestinal upset and restlessness. A fishy odor to the breath, sweat and urine has been reported. Although data are very limited, poor bioavailability might limit absorption by the breastfed infant. It appears unlikely that maternal levoCarnum supplements during nursing would be harmful to the infant, but until more data are available, it is probably best to avoid levoCarnum supplementation unless it is prescribed by a healthcare professional. Pasteurization (method not stated) had little effect on the concentration of endogenous Carnum in one study. Pasteurization followed by refrigeration at 5 degrees C for 48 hours reduced the Carnum concentration by about 13%.[3]

Alternate Drugs for Aminoacids, Enzymes and other Alimentary tract and Metabolism products. ATC A09 & A16

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