Question

I am a breastfeeding mother and i want to know if it is safe to use Mecloprodine Fumarate? Is Mecloprodine Fumarate safe for nursing mother and child? Does Mecloprodine Fumarate extracts into breast milk? Does Mecloprodine Fumarate has any long term or short term side effects on infants? Can Mecloprodine Fumarate influence milk supply or can Mecloprodine Fumarate decrease milk supply in lactating mothers?

Mecloprodine Fumarate lactation summary

Mecloprodine Fumarate usage has low risk in breastfeeding
  • DrLact safety Score for Mecloprodine Fumarate is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Mecloprodine Fumarate may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Mecloprodine Fumarate may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Mecloprodine Fumarate low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Mecloprodine Fumarate We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Mecloprodine Fumarate usage in lactation

1st generation antihistamine, ethanolamine, with moderate sedative and marked antimuscarinic effects. The latter could decrease prolactin production, which is important for milk production especially in the first few weeks. Their pharmacokinetic data (high volume of distribution and high percentage of plasma protein binding) explain the negligible excretion observed in milk (Kok 1982). However, there is a published case of a 10-week-old infant who showed signs of lethargy, irritability and rejection of feeding, although the mother took phenytoin and carbamazepine in addition to clemastine. No levels of clemastine were detected in the girl's plasma, who recovered well and continued to breastfeed (Kok 1982). Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity. Lethargy and adequate feeding of the infant should be monitored. Co-sleeping with the baby is not recommended if this drug is being taken (UNICEF 2013, Landa 2012, ABM 2008, UNICEF 2006).
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