Question

I am a breastfeeding mother and i want to know if it is safe to use 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine? Is 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine safe for nursing mother and child? Does 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine extracts into breast milk? Does 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine has any long term or short term side effects on infants? Can 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine influence milk supply or can 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine decrease milk supply in lactating mothers?

2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine lactation summary

2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine is unsafe in breastfeeding
  • DrLact safety Score for 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine .
  • It is recommended to evaluate the advantage of not breastfeeding while using 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine Vs not using 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine And continue breastfeeding.
  • While using 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine usage in lactation

Muscle-relaxant drug which is marketed in some countries and usually associated to acetaminophen. At latest update no published data were found on excretion into breast milk. Pharmacokinetic data favor excretion into breast milk. Convulsions have been reported in susceptible persons. There is a warning on likely mutagenic effects with a prolonged use.

Alternate Drugs for Muscle relaxants. ATC M03

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