Is NCI-C50259 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use NCI-C50259? Is NCI-C50259 safe for nursing mother and child? Does NCI-C50259 extracts into breast milk? Does NCI-C50259 has any long term or short term side effects on infants? Can NCI-C50259 influence milk supply or can NCI-C50259 decrease milk supply in lactating mothers?
NCI-C50259 lactation summary
- DrLact safety Score for NCI-C50259 is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of NCI-C50259 may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that NCI-C50259 may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using NCI-C50259 .
- Usage of NCI-C50259 is in contradiction to breastfeeding hence if it is must to use NCI-C50259 and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About NCI-C50259 usage in lactation
Drug is cleared from the body in 6 elimination half-lives. Resuming breastfeeding is likely safe after 3 pump-and-dump days. Regular milk expression and disposition to keep production and avoiding breast plethora or mastitis is desirable.
Alternate Drugs for Antineoplastic agents. ATC L01
Busulfan(Dangerous)
Cisplatin(Unsafe)
Cyclophosphamide(Dangerous)
Doxorubicin(Dangerous)
Etoposide(Dangerous)
Hydroxyurea(Low Risk)
Mercaptopurine(Safe)
Mitoxantrone(Dangerous)
Vincristine(Dangerous)
Methotrexate(Low Risk)
Imatinib(Unsafe)
Trastuzumab(Unsafe)
Bevacizumab(Low Risk)
Rituximab(Low Risk)
Alemtuzumab(Low Risk)
Fluorouracil(Dangerous)
Paclitaxel(Dangerous)
Carboplatin(Dangerous)
Cetuximab(Unsafe)
Brentuximab Vedotin(Low Risk)
Ipilimumab(Unsafe)
Everolimus(Unsafe)
Thioguanine(Dangerous)
Dacarbazine(Dangerous)
Vinorelbine(Dangerous)
Bleomycin(Dangerous)
Vinblastine(Dangerous)
Nivolumab(Unsafe)
Nilotinib(Unsafe)
Dasatinib(Unsafe)
Cladribine(Dangerous)
Erlotinib(Unsafe)
Pazopanib(Unsafe)
Capecitabine(Dangerous)
Docetaxel(Dangerous)
Carmustine(Dangerous)
Exemestane(Dangerous)
Gemcitabine(Dangerous)
Dactinomycin(Dangerous)
Epirubucin(Dangerous)
Fluorouracil Topical Solution(Low Risk)
Idarubicin-Hcl(Dangerous)
Ifosfamide(Dangerous)
Melphalan(Dangerous)
Mitomycin(Dangerous)
Oxaliplatin(Dangerous)
Pentostatin(Dangerous)
Procarbazine(Dangerous)
Teniposide(Dangerous)
Thiotepa(Dangerous)
Tretinoin Oral(Dangerous)
Vinorelbine Tartrate(Dangerous)
Imatinib Mesilate(Unsafe)
Altretamine(Dangerous)
Aminoglutethimide(Dangerous)
5-Aminolevulinic Acid(Low Risk)
Hydroxycarbamide(Low Risk)
Anastrozole(Dangerous)
Arsenic-Trioxide(Dangerous)
Asparaginase(Dangerous)
Bexarotene(Dangerous)
Cytarabine(Dangerous)
Chlorambucil(Dangerous)
Chlormethine(Dangerous)
Daunorubicin(Dangerous)
Rubidomycin(Dangerous)
Amethopterin(Low Risk)
Vincaleukoblastine(Dangerous)
Doxorubicin Hydrochloride(Dangerous)
Vlb(Dangerous)
Mechlorethamine(Dangerous)
Platinum Diamminodichloride(Unsafe)
4-Amino-10-methylfolic Acid(Low Risk)
5-ALA(Low Risk)
5-Fu(Dangerous)
6-Mercaptopurine(Safe)
6-Thiohypoxanthine(Safe)
6-Thioxopurine(Safe)
MTX(Low Risk)
Cytosine Arabinoside(Dangerous)
Daunomycin(Dangerous)
Actinomycin D(Dangerous)
Deoxycoformycin(Dangerous)