Question

I am a breastfeeding mother and i want to know if it is safe to use L-Asparaginase from Escherichia coli? Is L-Asparaginase from Escherichia coli safe for nursing mother and child? Does L-Asparaginase from Escherichia coli extracts into breast milk? Does L-Asparaginase from Escherichia coli has any long term or short term side effects on infants? Can L-Asparaginase from Escherichia coli influence milk supply or can L-Asparaginase from Escherichia coli decrease milk supply in lactating mothers?

L-Asparaginase from Escherichia coli lactation summary

L-Asparaginase from Escherichia coli is dangerous in breastfeeding
  • DrLact safety Score for L-Asparaginase from Escherichia coli is 7 out of 8 which is considered Dangerous as per our analyses.
  • A safety Score of 7 indicates that usage of L-Asparaginase from Escherichia coli may cause toxic or severe side effects in breastfed baby.
  • Our study of different scientific research indicates that L-Asparaginase from Escherichia coli may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using L-Asparaginase from Escherichia coli .
  • Usage of L-Asparaginase from Escherichia coli is in contradiction to breastfeeding hence if it is must to use L-Asparaginase from Escherichia coli and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About L-Asparaginase from Escherichia coli usage in lactation

Drug is cleared from the body in 5 half-lives elimination period. Resuming breastfeeding is likely safe after 10 pump-and-dump days period. Pumping is important to keep milk production.

Alternate Drugs for Antineoplastic agents. ATC L01

Busulfan(Dangerous)
Cisplatin(Unsafe)
Cyclophosphamide(Dangerous)
Doxorubicin(Dangerous)
Etoposide(Dangerous)
Hydroxyurea(Low Risk)
Mitoxantrone(Dangerous)
Vincristine(Dangerous)
Methotrexate(Low Risk)
Imatinib(Unsafe)
Trastuzumab(Unsafe)
Bevacizumab(Low Risk)
Rituximab(Low Risk)
Alemtuzumab(Low Risk)
Fluorouracil(Dangerous)
Paclitaxel(Dangerous)
Carboplatin(Dangerous)
Cetuximab(Unsafe)
Ipilimumab(Unsafe)
Everolimus(Unsafe)
Thioguanine(Dangerous)
Dacarbazine(Dangerous)
Vinorelbine(Dangerous)
Bleomycin(Dangerous)
Vinblastine(Dangerous)
Nivolumab(Unsafe)
Nilotinib(Unsafe)
Dasatinib(Unsafe)
Cladribine(Dangerous)
Erlotinib(Unsafe)
Pazopanib(Unsafe)
Capecitabine(Dangerous)
Docetaxel(Dangerous)
Carmustine(Dangerous)
Exemestane(Dangerous)
Gemcitabine(Dangerous)
Dactinomycin(Dangerous)
Epirubucin(Dangerous)
Idarubicin-Hcl(Dangerous)
Ifosfamide(Dangerous)
Melphalan(Dangerous)
Mitomycin(Dangerous)
Oxaliplatin(Dangerous)
Pentostatin(Dangerous)
Procarbazine(Dangerous)
Teniposide(Dangerous)
Thiotepa(Dangerous)
Tretinoin Oral(Dangerous)
Altretamine(Dangerous)
Anastrozole(Dangerous)
Arsenic-Trioxide(Dangerous)
Asparaginase(Dangerous)
Bexarotene(Dangerous)
Cytarabine(Dangerous)
Chlorambucil(Dangerous)
Chlormethine(Dangerous)
Daunorubicin(Dangerous)
Rubidomycin(Dangerous)
Amethopterin(Low Risk)
Vlb(Dangerous)
Mechlorethamine(Dangerous)
5-ALA(Low Risk)
5-Fu(Dangerous)
MTX(Low Risk)
Daunomycin(Dangerous)
Actinomycin D(Dangerous)
Deoxycoformycin(Dangerous)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.