Is Sodium alendronate hydrate Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Sodium alendronate hydrate? Is Sodium alendronate hydrate safe for nursing mother and child? Does Sodium alendronate hydrate extracts into breast milk? Does Sodium alendronate hydrate has any long term or short term side effects on infants? Can Sodium alendronate hydrate influence milk supply or can Sodium alendronate hydrate decrease milk supply in lactating mothers?
Sodium alendronate hydrate lactation summary
- DrLact safety Score for Sodium alendronate hydrate is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Sodium alendronate hydrate may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Sodium alendronate hydrate may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Sodium alendronate hydrate low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Sodium alendronate hydrate We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Sodium alendronate hydrate usage in lactation
It is composed by bisphosphonates. Most bisphosphonates are acidic compounds that achieve low plasma concentration. Both features make it unlikely excretion into the milk in clinically significant amount. Alendronate has shown very low plasma concentrations (<5 ng / ml). Intestinal absorption of bisphosphonates is very low even during fasting and is considered negligible in the presence of milk due to formation with the calcium of non absorbable compounds. A latest update no published data were found on excretion in the breast milk. Until more data about this drug regarding breastfeeding is available, safer known alternatives (e.g. pamidronate) should be of choice, especially in the neonatal period and in case of prematurity.
Answer by DrLact: About Sodium alendronate hydrate usage in lactation
Limited evidence indicates that breastfeeding after cessation of long-term bisphosphonate treatment appears to have no adverse effects on the infant. Because no information is available on the use of alendronate during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of alendronate by a breastfed infant is unlikely. If the mother receives a bisphosphonate during pregnancy or nursing, some experts recommend monitoring the infant's serum calcium during the first 2 months postpartum.[1]
Sodium alendronate hydrate Side Effects in Breastfeeding
Because alendronate can persist in the body for years after long-term administration, the following cases may be relevant. A woman received alendronate for 6 months, then pamidronate every 4 months for 1 year prior to conception. Her infant was breastfed (extent not stated) for 3 months. The infant had mild hypocalcemia at 2 months of age, but a normal calcium level and normal long bone development at 5 months of age.[2]
Alternate Drugs for Drugs for Bone Diseases and Mineralization. M05
Alendronate(Low Risk)
Ibandronate(Low Risk)
Risedronate(Low Risk)
Denosumab(Low Risk)
Alendronate Sodium(Low Risk)
Pamidronate Disodium(Safe)
Etidronate Disodium(Low Risk)
Risedronate Sodium(Low Risk)
Tiludronate Sodium(Low Risk)
Zoledronate Disodium(Low Risk)
Ibandronate Sodium(Low Risk)