Is APD Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use APD? Is APD safe for nursing mother and child? Does APD extracts into breast milk? Does APD has any long term or short term side effects on infants? Can APD influence milk supply or can APD decrease milk supply in lactating mothers?
APD lactation summary
- DrLact safety Score for APD is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of APD is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that APD does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of APD safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About APD usage in lactation
It is composed by bisphosphonates Most bisphosphonates are acidic compounds that achieve low plasma concentration. Both features make it unlikely excretion into the milk in clinically significant amount. Intestinal absorption of bisphosphonates is very low even during fasting and is considered negligible in the presence of milk due to formation with the calcium of non absorbable compounds. Pamidronate is excreted into breast milk in clinically insignificant amount and no problems have been observed in infants whose mothers were treated, except some cases of mild and asymptomatic hypocalcemia in infants whose mothers had been already treated before and / or during pregnancy, so some authors suggest regular monitoring of serum calcium.
Alternate Drugs for Drugs for Bone Diseases and Mineralization. M05
Alendronate(Low Risk)
Ibandronate(Low Risk)
Risedronate(Low Risk)
Denosumab(Low Risk)
Alendronate Sodium(Low Risk)
Pamidronate Disodium(Safe)
Etidronate Disodium(Low Risk)
Risedronate Sodium(Low Risk)
Tiludronate Sodium(Low Risk)
Zoledronate Disodium(Low Risk)
Ibandronate Sodium(Low Risk)