Is Polymixin E Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Polymixin E? Is Polymixin E safe for nursing mother and child? Does Polymixin E extracts into breast milk? Does Polymixin E has any long term or short term side effects on infants? Can Polymixin E influence milk supply or can Polymixin E decrease milk supply in lactating mothers?
Polymixin E lactation summary
- DrLact safety Score for Polymixin E is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Polymixin E is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Polymixin E does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Polymixin E safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Polymixin E usage in lactation
Pharmacokinetic data (high volume of distribution and molecular weight) would explain the minimal excretion into breast milk mentioned in two older reports. Due to a poor oral bioavailability, appearance in the infant's plasma from ingested milk is regarded as nil or scanty, except in premature infants or during the immediate neonatal period who may show an increased intestinal absorption.