Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-75046A1XTN? Is UNII-75046A1XTN safe for nursing mother and child? Does UNII-75046A1XTN extracts into breast milk? Does UNII-75046A1XTN has any long term or short term side effects on infants? Can UNII-75046A1XTN influence milk supply or can UNII-75046A1XTN decrease milk supply in lactating mothers?

UNII-75046A1XTN lactation summary

UNII-75046A1XTN is unsafe in breastfeeding
  • DrLact safety Score for UNII-75046A1XTN is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of UNII-75046A1XTN may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that UNII-75046A1XTN may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using UNII-75046A1XTN .
  • It is recommended to evaluate the advantage of not breastfeeding while using UNII-75046A1XTN Vs not using UNII-75046A1XTN And continue breastfeeding.
  • While using UNII-75046A1XTN Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-75046A1XTN usage in lactation

Alpha-1 adrenergic blocker that is used on benign prostatic hypertrophy and other problems like voiding difficulty and obstruction including those caused by lithiasis. At latest update relevant published data on its excretion into breast milk were not found. Because of a high protein-binding capacity it is unlikely an excretion into breastmilk in significant amounts. Use not indicated on women. Several studies have reported usefulness for the removal of urinary stones. There is no evidence of efficacy in the prevention of post-traumatic urinary retention. Since it may cause hypotension in the infant, until more data on this drug is available, a safer and known alternative may be preferable, especially in cases of nursing infants younger than one month of age and premature babies.

Alternate Drugs for Urologicals: Antispasmodics, Erectile dysfunction and Benign prostatic hypertrophy. ATC G04

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