Is BAY38-9456 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use BAY38-9456? Is BAY38-9456 safe for nursing mother and child? Does BAY38-9456 extracts into breast milk? Does BAY38-9456 has any long term or short term side effects on infants? Can BAY38-9456 influence milk supply or can BAY38-9456 decrease milk supply in lactating mothers?
BAY38-9456 lactation summary
- DrLact safety Score for BAY38-9456 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of BAY38-9456 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that BAY38-9456 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of BAY38-9456 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using BAY38-9456 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About BAY38-9456 usage in lactation
A 5-phosphodiesterase inhibitor with uses similar to sildenafil, used in the treatment of pulmonary hypertension, erectile dysfunction in men, Raynaud's syndrome and in other treatments due to its vasodilatory effect on smooth muscle. Since the last update, we have not found published data on its excretion in breast milk. Its high percentage of protein binding makes it unlikely that it will be transferred to milk in significant amounts, as in fact has been seen in another drug from the same therapeutic group, sildenafil. Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.
Alternate Drugs for Urologicals: Antispasmodics, Erectile dysfunction and Benign prostatic hypertrophy. ATC G04
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Oxybutinyn(Low Risk)
Solifenacin(Unsafe)
Tolterodine(Low Risk)
Sildenafil(Safe)
Fesoterodine(Low Risk)
Flavoxate(Low Risk)
Alfuzosin Hydrochloride(Unsafe)
Oxybutynin(Low Risk)
Tamsulosin(Low Risk)
Tolterodine Tartrate(Low Risk)
Darifenacin(Low Risk)
Flavoxate Hydrochloride(Low Risk)
Trospium-Chloride(Low Risk)
Tadalafil(Low Risk)
Vardenafil(Low Risk)
Vardenafil Hydrochloride(Low Risk)
Sildenafil Citrate(Safe)
Phenazopyridine Hydrochloride(Low Risk)
Fesoterodine Fumarate(Low Risk)
Tamsulosin Hydrochloride(Low Risk)