Question

I am a breastfeeding mother and i want to know if it is safe to use IDEC-102; IDEC-C2B8; R-105? Is IDEC-102; IDEC-C2B8; R-105 safe for nursing mother and child? Does IDEC-102; IDEC-C2B8; R-105 extracts into breast milk? Does IDEC-102; IDEC-C2B8; R-105 has any long term or short term side effects on infants? Can IDEC-102; IDEC-C2B8; R-105 influence milk supply or can IDEC-102; IDEC-C2B8; R-105 decrease milk supply in lactating mothers?

IDEC-102; IDEC-C2B8; R-105 lactation summary

IDEC-102; IDEC-C2B8; R-105 usage has low risk in breastfeeding
  • DrLact safety Score for IDEC-102; IDEC-C2B8; R-105 is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of IDEC-102; IDEC-C2B8; R-105 may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that IDEC-102; IDEC-C2B8; R-105 may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of IDEC-102; IDEC-C2B8; R-105 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using IDEC-102; IDEC-C2B8; R-105 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About IDEC-102; IDEC-C2B8; R-105 usage in lactation

Monoclonal antibody which is an immunoglobulin G with anti-CD20 activity that contains 664 amino acids. Indicated for treatment of Rheumatoid Arthritis, Hodgkin Lymphoma and Chronic Lymphoid Leukemia. At latest update relevant data on breastfeeding were not found. Because of a high molecular weight, excretion into breast milk is very unlikely. Its low oral bioavailability makes that serum levels in the infant that could be originated from milk absorption are to be absent or scanty, except in premature infants or in the early period after birth in which gut absorption may be increased. Many reports have not shown harmful effects in the infant after long-lasting intrauterine exposure . However, despite it is thought to be safe while breastfeeding, and, until more data on this drug is available, in cases of Rheumatoid Arthritis a known safer alternative should be used.
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