Is Phthalazinone, hydrazone, monohydrochloride Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Phthalazinone, hydrazone, monohydrochloride? Is Phthalazinone, hydrazone, monohydrochloride safe for nursing mother and child? Does Phthalazinone, hydrazone, monohydrochloride extracts into breast milk? Does Phthalazinone, hydrazone, monohydrochloride has any long term or short term side effects on infants? Can Phthalazinone, hydrazone, monohydrochloride influence milk supply or can Phthalazinone, hydrazone, monohydrochloride decrease milk supply in lactating mothers?
Phthalazinone, hydrazone, monohydrochloride lactation summary
- DrLact safety Score for Phthalazinone, hydrazone, monohydrochloride is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Phthalazinone, hydrazone, monohydrochloride is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Phthalazinone, hydrazone, monohydrochloride does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Phthalazinone, hydrazone, monohydrochloride safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Phthalazinone, hydrazone, monohydrochloride usage in lactation
It is excreted into breast milk in clinically non-significant amount. No problem was observed in infants whose mothers were on this medication.Plasma levels in those infants were undetectable or very low. The American Academy of Pediatrics rates it as a medication usually compatible with breastfeeding.WHO List of Essential Medicines 2002: compatible with breastfeeding.
Answer by DrLact: About Phthalazinone, hydrazone, monohydrochloride usage in lactation
Limited milk level and infant serum level data and a long history of use in postpartum mothers indicate that hydralazine is an acceptable antihypertensive in nursing mothers, even those nursing newborns.
Phthalazinone, hydrazone, monohydrochloride Side Effects in Breastfeeding
No adverse effects reported in one infant breastfed for 8 weeks.[1]
Alternate Drugs for Anti-hypertensive Anti Alpha-adrenergics, Vasodilators & other. ATC C02
Hydralazine(Safe)
Methyldopa(Safe)
Minoxidil(Safe)
Reserpine(Unsafe)
Guanfacine(Low Risk)
Doxazosin(Safe)
Prazosin(Unsafe)
Terazosin(Unsafe)
Bosentan(Low Risk)
Clonidine-Hcl(Low Risk)
Diazoxide(Unsafe)
Doxazosin Mesylate(Safe)
Moxonidine(Unsafe)
Nitroprussiate(Unsafe)
Urapidil-Hcl(Unsafe)