Is NSC 10464 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use NSC 10464? Is NSC 10464 safe for nursing mother and child? Does NSC 10464 extracts into breast milk? Does NSC 10464 has any long term or short term side effects on infants? Can NSC 10464 influence milk supply or can NSC 10464 decrease milk supply in lactating mothers?

NSC 10464 lactation summary

DrLact safety Score for NSC 10464 is 7 out of 8 which is considered Dangerous as per our analyses.
A safety Score of 7 indicates that usage of NSC 10464 may cause toxic or severe side effects in breastfed baby.
Our study of different scientific research indicates that NSC 10464 may cause moderate to high side effects or may affect milk supply in lactating mother.
Our suggestion is to use safer alternate options rather than using NSC 10464 .
Usage of NSC 10464 is in contradiction to breastfeeding hence if it is must to use NSC 10464 and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About NSC 10464 usage in lactation

Stimulants, cathartic laxative drug which is irritant to intestinal mucosa. Risk of diarrhea among toddlers. Safer laxative drugs are those bulk-inducing, osmotic, emollient or stool softener agents. A balanced and fiber-rich diet, high fluid intake and physical exercise are of paramount importance to fight constipation. There are evidence of carcinogenicity from studies in experimental animals.