Is Busulfan Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Busulfan? Is Busulfan safe for nursing mother and child? Does Busulfan extracts into breast milk? Does Busulfan has any long term or short term side effects on infants? Can Busulfan influence milk supply or can Busulfan decrease milk supply in lactating mothers?

Drug is cleared from the body in 10 elimination half-lives. Resuming breastfeeding is likely safe after 24 hours of pumping-and-dumping.

Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy.[1] It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence. Although minimal data are available to determine an appropriate period to withhold breastfeeding, the drug's terminal half-live of 2.5 hours suggests that withholding breastfeeding for at least 24 hours may be sufficient. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[3]

Busulfan in a dosage of 4 mg/day for 5 weeks was taken for myeloid leukemia by one woman while breastfeeding. Weekly monitoring found no adverse effects on her infant's leukocyte count or hemoglobin.[3]