Question

I am a breastfeeding mother and i want to know if it is safe to use Midazolam? Is Midazolam safe for nursing mother and child? Does Midazolam extracts into breast milk? Does Midazolam has any long term or short term side effects on infants? Can Midazolam influence milk supply or can Midazolam decrease milk supply in lactating mothers?

Midazolam lactation summary

Midazolam is safe in breastfeeding
  • DrLact safety Score for Midazolam is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Midazolam is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Midazolam does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Midazolam safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Midazolam usage in lactation

Used for sedation in preoperative anesthetic procedures. After 4 hours there is not any trace of the drug in mother’s blood.

Answer by DrLact: About Midazolam usage in lactation

The small amounts of midazolam excreted into breastmilk would not be expected to cause adverse effects in most breastfed infants. Two expert panels advocates waiting for at least 4 hours after a single intravenous dose of midazolam (e.g., for endoscopy) before resuming nursing.[1][2] However, no waiting period or discarding of milk might be necessary before resuming breastfeeding after a single dose of midazolam in the mothers of infants over 2 months of age. After general anesthesia, breastfeeding can be resumed as soon as the mother has recovered sufficiently from general anesthesia to nurse.[3][4][5] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure. With prolonged use (days) of intravenous therapy, an active metabolite can accumulate in the mother and might affect the infant, but data in breastfeeding are lacking.

Midazolam Side Effects in Breastfeeding

In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. Nineteen mothers took midazolam (presumably orally) while breastfeeding and none reported sedation in her infant.[9]

Alternate Drugs

Sufentanil(Low Risk)
Fentanyl(Safe)
Remifentanil(Low Risk)
Propofol(Safe)
Ketamine(Low Risk)
Midazolam(Safe)
Temazepam(Low Risk)
Lorazepam(Safe)
Quazepam(Unsafe)
Diazepam(Low Risk)
Clorazepate(Low Risk)
Oxazepam(Safe)
Alprazolam(Low Risk)
Midazolam(Safe)
Nitrazepam(Low Risk)
Meprobamate(Low Risk)
Lorazepam(Safe)
Temazepam(Low Risk)
Quazepam(Unsafe)
Diazepam(Low Risk)
Clorazepate(Low Risk)
Clobazam(Low Risk)
Oxazepam(Safe)
Estazolam(Low Risk)
Clonazepam(Low Risk)
Alprazolam(Low Risk)
Flurazepam(Unsafe)
Midazolam(Safe)
Nitrazepam(Low Risk)
Butabarbital(Low Risk)
Temazepam(Low Risk)
Pentobarbital(Low Risk)
Lorazepam(Safe)
Secobarbital(Low Risk)
Eszopiclone(Low Risk)
Propofol(Safe)
Ketamine(Low Risk)
Quazepam(Unsafe)
Diazepam(Low Risk)
Phenobarbital(Low Risk)
Estazolam(Low Risk)
Sodium Oxybate(Low Risk)
Clorazepate(Low Risk)
Oxazepam(Safe)
Flurazepam(Unsafe)
Chloral Hydrate(Low Risk)
Zolpidem(Safe)
Meprobamate(Low Risk)
Zaleplon(Safe)
Alprazolam(Low Risk)
Midazolam(Safe)
Nitrazepam(Low Risk)
Triazolam(Low Risk)
Butalbital(Low Risk)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.